Taller 2. Use of genome-wide data in the social sciences

13 Junio 2016 10:00 am - 17 Junio 2016 2:00 pm

El Colegio de México, Ciudad de México

Taller 2. Use of genome-wide data in the social sciences

Genome-wide data is increasingly available for studies of interest to non-geneticists. This workshop provides hands-on instruction in how to implement the key techniques and methods require to answer research questions that are tractable given genome-wide data. It covers the basics of working with genome-wide data including conducting quality control, population stratification, understanding GWAS results, and the construction of polygenic scores. 

Resumen: As costs associated with genotyping plummet, genome-wide data is increasingly available for studies of interest to non-geneticists. However, working with such data is not a trivial matter. This workshop aims to build competencies in the key areas needed so that, after the workshop, attendees can first identify research questions of interest to them that involve genome-wide data and then go about answering them using the relevant tools and techniques! Attendees will get an overview of the key scholarship from various fields (e.g., population genetics, statistical genetics, sociogenomics) so as to orient them towards the type of research questions that are tractable given genome-wide data. The workshop will also provide hands-on instruction in how to implement the key techniques and methods require to answer such research questions.

The workshop will focus on the following hands-on techniques:

•Quality control techniques needed to identify a set of genetic markers, which have been accurately genotyped;

•Issues related to understanding population stratification and admixture;

•How to interpret GWAS results;

•How to construct, test, and interpret polygenic scores;

•How to compute genetic relatedness and how to use such measures in the subsequent computation of heritability (and the potential problems with this idea).

In the course of covering these techniques, a variety of software will be used (including plink, GCTA, PRSice, king, and admixture). To ensure that attendees all have common access to data and software tools, the hands-on component of the workshop will take place on Amazon EC2 instances.